|Recent advancements in a wide range of instrumentation including high-resolution electron and optical microscopes,|
chemical analyzers, and spectroscopes allow researchers to see and manipulate matter with unprecedented precision and
accuracy. However, despite large investments by universities, government facilities, and industry in these instruments
and capabilities, sample preparation and poor sample quality continue to impede characterization accuracy, reproducibility,
and throughput. Poor sample preparation creates artifacts such as aggregation or sample damage that introduce uncertainty in data and analysis and that often require multiple samples for a
single quality data point or image.